I found the first few paragraphs of this New York Times article, Video Artists Escape Hollywood Sensibility pretty interesting. They talk about the way some people have been using video games as the basis for making "Art".

In my opinion some games are pretty close to Art, if not already there, even without reinterpretation. This isn't about that though, it's about creating someting new by looking at a game from a different perspective, not the one the game makers had in mind. Even if you don't agree games are Art I think you've got to admit that the idea of approaching Grand Theft Auto, as if the protagonist were a Canadian tourist, instead of the violent criminal he's meant to be, and recording a virtual tour of the setting, Liberty City, is clever. The resulting video can be seen at My Trip to Liberty City. I'm intrigued by these sorts of repurposings.